How duplicate genes provide genetic robustness remains an unresolved question.We have examined the duplicated histone deacetylases Sir2p and Hst1p in Saccharomyces cerevisiae and find that these paralogs with non-overlapping functions can The Midi provide genetic robustness against null mutations through a substitution mechanism.Hst1p is an NAD(+)-
Live 4D-OCT denoising with self-supervised deep learning
Abstract By providing three-dimensional visualization of tissues and instruments at high resolution, live volumetric optical coherence tomography (4D-OCT) has the potential to revolutionize ophthalmic surgery.However, the necessary imaging speed is accompanied by increased noise levels.A high data rate and the requirement MODUCARE for minimal laten
Detection of Financial Reporting Fraud: The Case of Socially Responsible Firms
This study aims to analyze the implementation of fraud pentagon theory, covering pressure, opportunity, rationalization, competence, and arrogance variables on financial statement fraud using the Beneish M-score method for socially responsible companies listed in the SRI-KEHATI index of the Indonesia Stock Exchange in the period 2013-2018.The secon